时间：2023年6月16日（周五）14:20-15:50 

Time：2:20-3:50 PM, Friday, June 16th, 2023

地点：西湖大学云谷校区学术环E10-201

Venue:  E10-201, Yungu Campus

主持人：西湖大学生命科学学院 教授黄志伟

Host: Professor Zhiwei Huang, School of Life Sciences

Dr. Jason George Cyster

 Vice chair, Dept. of Microbiol. & Immunol., University of California, San Francisco

Dr. Cyster has 27 years experience managing an NIH and HHMI funded immunology research laboratory. His research has involved defining the migration cues and intercellular communications acting to support protective humoral immune responses and to avoid autoantibody-mediated disease. His group uses immunological, genetic, cell biological and advanced imaging techniques to study these processes. They perform mechanistic studies using mouse models and, in several cases, they have translated their work to humans While many of their studies are performed using the mouse as a model, in several cases they have translated their work to humans, such as their identification of a novel gene pathway that is disrupted in germinal center B cell-type diffuse large B cell lymphoma (GCB-DLBCL). His mouse studies defining the mechanism of lymphocyte egress from lymphoid organs provided insights that helped in the FDA approval of an egress antagonist, Fingolimod, as a treatment for multiple sclerosis.

报告题目/Title: 

Deciphering the Guidance Cue Code for Immunity

讲座摘要/Abstract: 

Getting the right cells to the right place at the right time is critical for immune system function. For many years we have studied the migration cues and receptors needed for directing immune cell migration and confinement within lymphoid niches. In this talk I will provide an update on our discovery of the mechanism of lymphocyte egress from lymphoid tissues, and the role of CD69 as an egress regulator. I will then describe our recent discovery of GPR35 as a chemoattractant receptor in neutrophils that responds to the serotonin metabolite 5-HIAA that is produced by activated platelets and mast cells. We find that GPR35 – 5-HIAA mediates eosinophil recruitment to the Cryptococcus neoformans infected lung, exacerbating disease by favoring type II immunity. Finally, I will discuss our discovery that the adhesion GPCR, Adgre5 (CD97), mechanosenses red blood cells and signals via Ga13 and RhoA to mediate dendritic cell and marginal zone B cell retention in the spleen.

讲座联系人/Contact:

科技合作部sci-tech02@westlake.edu.cn